OBESITY

Measures:

Lab Studies:

Additional Lab Studies: May be required in a child with obesity:

Imaging Studies:

Additional Studies for Obesity-Hypoventilation Syndrome:

 Additional Studies for Insulin Resistance:

Additional Studies for Prader-Willi Syndrome:

  • Genetic testing can be done for PWS. The tests include:
    • Chromosomal analysis and assessment for methylation patterns in the PWS region. Methylation patterns can be determined by PCR using DNA primers, which detect methylated cytosine, or by Southern blot hybridization. Samples should be taken from both parents and the child with PWS. This would enable analysis for uniparental disomy.
    • Prenatal diagnosis requires chorionic villus sampling or amniocentesis in the first hand. If deletion in the 15q region is suspected, it can be confirmed by Fluorescent in situ hybridization (FISH).
    • If imprinting centre mutation is found in a given patient, we should proceed to testing both parents of the given patient for the presence of asymptomatic mutations in the imprinting centre. If found, it suggests a high likelihood of recurrence.
  • Medline Plus: Karyotyping (when Prader-Willi syndrome [15q-] is suspected) - http://www.nlm.nih.gov/medlineplus/ency/article/003935.htm
  • American Association of Clinical Chemistry: Insulin-like Growth Factor - 1 (IGF-1) - also known as Somatomedin C - http://www.labtestsonline.org/understanding/analytes/igf1/glance.html
  • Medline Plus: Bone mineral density (BMD) test: The aim is to detect and monitor osteoporosis- http://www.nlm.nih.gov/medlineplus/ency/article/007197.htm
  • Medline Plus: Chest X-ray: Done if cor-pulmonale is suspected- http://www.nlm.nih.gov/medlineplus/ency/article/003804.htm

Standard Anthropometric Measurements: The aim is to estimate the degree of visceral and subcutaneous fat.

Estimation of Skin Thickness:

Risk Assessment Tools:

Questionnaire:

Statistics:

Document Provenance and History

Document Author: Dr. Fazal Danish

Document Created: 29th March 2006

Document Edits:

 

© 2005-2006 Online Encyclopedia for Genetic Epidemiology studies (www.oege.org ). Please contact webmaster@oege.org with any enquiries or contributions.
No guarantees are made of the accuracy or completeness of this site, and no liability can be accepted for any losses resulting from its use.